Lower Manic Fringe Expression as an Independent Prognostic Biomarker and Correlated with Immune Suppression of Tumor Microenvironment in Lung Adenocarcinoma

Non-small cell lung cancer is the leading cause of cancer-associated mortality worldwide and adenocarcinoma its most common type. The fringe protein family can modulate Notch receptors to regulate pathways affect a variety physiological processes, such as embryo development tumor formation. To investigate influence manic expression on prognosis patients evaluate correlation with immune suppression microenvironment objective study. Wilcoxon rank test logistic regression were used analyze relationship between clinical characteristics adenocarcinoma. was analyzed using Kaplan- Meier plotter analysis Cox regression, receiver operating characteristic curve nomogram constructed. Single sample gene set enrichment infiltration. in verified Oncomine estimation resource database. Manic significantly lower than that normal tissues. Kaplan-Meier revealed overall survival disease-specific low shorter (p<0.05) those high expression. Multivariate further confirmed an independent predictor longer Furthermore, other clinicopathological features, tumour lymph nodes classification residual R classification, correlated worse prognosis. showed infiltration interdigitating dendritic cells cells. may be prognostic biomarker associated